Introduction to proteins and enzymes, carbohydrate metabolism, and glucose homeostasis. The course emphasis is on human biochemistry and it is designed for students going into health science fields. Credit will be granted for only one of BIOC 202, BIOC 203 or BIOL 201. [3-0-0] Prerequisite: One of CHEM 203, CHEM 223, CHEM 233.
Amino acids and proteins. Enzymes and enzymology. Human metabolic pathways. Structure, function and metabolism of carbohydrates including glycogen storage and gluconeogenesis. Restricted to students in Biochemistry specializations. Credit will be granted for only one of BIOC 202, BIOC 203 or BIOL 201. [3-0-1] Prerequisite: BIOL 200 and one of CHEM 203, CHEM 223. Corequisite: CHEM 213.
Techniques by which the chemical and physical properties of fundamental components of the cell are studied. [0-3-1] Corequisite: One of BIOC 302, BIOC 303.
Metabolic reactions of lipids, steroids, amino acids and nucleotides; the biochemistry of replication, transcription and translation. Credit will be granted for only one of BIOC 302 or BIOC 303. [3-0-1] Prerequisite: One of BIOL 201, BIOC 202, BIOC 203 and one of CHEM 203, CHEM 223, CHEM 233. Equivalency: BIOC 303
Structure, function and metabolism of lipids, steroids, amino acids and nucleotides; the biochemistry and molecular biology of replication, transcription, translation and gene regulation. For students in Biochemistry and Honours programs in other life sciences. Credit will be granted for only one of BIOC 302 or BIOC 303. [3-0-0] Prerequisite: One of BIOC 203, BIOC 202, BIOL 201 and either (a) CHEM 213 or (b) CHEM 233.
Exploration of the breadth and importance of biochemical research to present day challenges in medicine and biotechnology. Detailed experimental research case studies of novel biochemical methods used to address pressing and ongoing biochemical issues. [3-0-0] Prerequisite: CHEM 213. Corequisite: BIOC 303.
Quantitative and computational methods of biological information transfer. Methods; data analysis approaches and theories involved in bioinformatics; computational biology and high-throughput data. [3-0-0] Prerequisites: a) BIOC 203 and a corequisite of BIOC 303 or b) One of BIOC 202 or BIOL 201 with a grade of 76% or higher and a corequisite of BIOC 302.
Approved and supervised technical work experience in an industrial or academic laboratory for three or four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. Prerequisite: Completion of academic third year in Biochemistry major or honours program is required. This course is not eligible for Credit/D/Fail grading.
Approved and supervised technical work experience in an industrial or academic research setting for four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. Prerequisite: BIOC398 This course is not eligible for Credit/D/Fail grading.
Structural components of proteins, classification by primary, secondary and tertiary structure, protein chemistry and purification, peptide and protein synthesis by chemical means and three-dimensional structure determination using X-ray diffraction and NMR. [3-0-0] Prerequisite: One of BIOC 302, BIOC 303, BIOT 380. A minimum standing of 65% is recommended in these courses.
Kinetic analysis, catalytic mechanisms, transition state stabilization and regulation of activity, strategies for active site characterization and case studies of well-documented enzyme systems. Credit will be granted for only one of BIOC 403, CHEM 413 or CHEM 569. [3-0-0] Prerequisite: BIOC402 A minimum standing of 65% is recommended.
Theory and application of classical and emerging technologies in biochemical research. Emphasis on using primary literature and oral presentation skills. Restricted to Honours students in Biochemistry or others with permission of the instructor. [1-0; 2-0]
Chemical, physical and biological properties of nucleic acids and their role in replication, transcription, translation and regulation of expression of genetic material. Credit will be granted for only one of BIOC 410 or BIOC 510. [3-0-0] Prerequisite: Either (a) all of BIOC 303, BIOL 335 or (b) BIOT 380. A minimum standing of 65% is recommended in these courses.
Multi-week experiments in areas of contemporary biochemistry research using classical and modern techniques. Emphasis on experimental design, technique, critical analysis of data, and scientific communication skills. Restricted to Honours students in Biochemistry and others with permission of the instructor. [0-6-0] Corequisite: One of BIOC 404, FSCT 480.
Multi-week experiments involving contemporary nucleic acid research, cloning and recombinant protein engineering. Emphasis is on experimental design, critical analysis of data and scientific communication skills. Restricted to Major students in Biochemistry. [0-6-0] Prerequisite: All of BIOC 301, BIOC 410.
Advanced topics in protein structure and function. [3-0-0] Prerequisites: BIOC 402
Developing areas of molecular biology, focusing on experimental design and data analysis. Signal transduction, the use of model eukaryotes, and the regulation of gene expression. [3-0-0] Prerequisite: One of BIOC 303, BIOT 380 and all of BIOC 402, BIOC 410.
A library (3 credits) or a laboratory project with written report (3 or 6 credits) allowing a student to undertake an investigation on a specific topic as agreed upon by the faculty and student. Prerequisite: Permission of the Department Head is required.
A research problem under the direction of a faculty member. Restricted to Honours students.
Biochemistry of membranes and membrane proteins, membrane fusion, electrical signaling, and the involvement of membrane proteins in disease and drug development. [3-0-0] Prerequisite: One of BIOC 303, BIOT 380 and all of BIOC 402, BIOC 410.
Theoretical basis and practical applications of a selection of advanced techniques currently used in biochemical research. Topics will vary. [3-0-0] Prerequisite: One of BIOC 303, BIOT 380 and all of BIOC 402, BIOC 410.
Biochemical basis of select global challenges. Critical evaluation of primary literature to form evidence-based opinions and communicating biochemistry as it relates to several controversial societal issues. [3-0-1] Prerequisite: One of BIOC 302, BIOC 303.
Self-directed, collaborative studies, in a group-learning environment, initiated and coordinated by senior undergraduate students with the supervision of a faculty advisor. Course structure, enrolment, and delivery methods will comply with the Handbook for Student Directed Seminars. Not given every year. [3-0-0] Prerequisite: Third-year standing. Corequisite: One of BIOC 302, BIOC 303.
Approved and supervised technical work experience in an industrial or academic research setting for four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. Prerequisite: BIOC399 This course is not eligible for Credit/D/Fail grading.
Approved and supervised technical work experience in an industrial or academic research setting for four months. Technical report required. Restricted to students admitted to the Internship Program in Biochemistry and Molecular Biology. Prerequisite: BIOC498 This course is not eligible for Credit/D/Fail grading.
Practical applications of advanced biochemical techniques. Admission is limited and is by permission of the department head. This course is not eligible for Credit/D/Fail grading.
The physical properties and functional roles of lipids in membranes, liposomes, membrane permiability; membrane function; structure, biosynthesis and cell sorting of membrane proteins; and the structure-function relationships of channels, transporters and receptors. Given in alternate years. [3-0] This course is not eligible for Credit/D/Fail grading.
Structure and function of nucleic acids and their role in replication, transcription, translation and expression of genetic information. Credit will be granted for only one of BIOC 410 or BIOC 510. [3-0] This course is not eligible for Credit/D/Fail grading.
A lecture and discussion course on the molecular basis of cellular regulation with special emphasis on mammalian cells. Mechanisms involved in the responses of cells to adrenergic, steroid and peptide hormones and growth factors. Regulation of the concentration and specific activity of key enzymes, transport systems and structural proteins. Given in alternate years. [3-0] This course is not eligible for Credit/D/Fail grading.
Topics will include contemporary theoretical and experimental investigation of protein structure-function relationships. Topics will vary. Given in alternate years. [3-0] This course is not eligible for Credit/D/Fail grading.
Structure, biosynthesis and cell sorting of membrane proteins; and the structure-function relationships of channels, transporters and receptors. This course is not eligible for Credit/D/Fail grading.
Attendance is required of all graduate students in Biochemistry. Normally students will make a presentation once per year on a topic approved by their research advisor or committee or on the results of their research. This course is not eligible for Credit/D/Fail grading.
In special cases, with approval of the department head, advanced courses may be arranged for graduate students in attendance. This course is not eligible for Credit/D/Fail grading.
This course is not eligible for Credit/D/Fail grading.
Discussions based on topics in the current literature. [3-0] This course is not eligible for Credit/D/Fail grading.
Structure, biosynthesis and cell sorting of membrane proteins; and the structure-function relationships of channels, transporters and receptors. This course is not eligible for Credit/D/Fail grading.
Principles of lipid structure and dynamics; biochemical approaches to study lipids and applications of lipid biology. This course is not eligible for Credit/D/Fail grading.
Mechanisms, regulation and dynamics of DNA and RNA biology. Structure and function of nucleic acids and their role in replication, transcription, translation and expression of genetic information. This course is not eligible for Credit/D/Fail grading.
Principles, regulation and dynamics of epigenetics. This course is not eligible for Credit/D/Fail grading.
Mechanisms involved in the responses of cells to adrenergic, steroid and peptide hormones and growth factors. Recent advances in approaches and regulation of the concentration and specific activity of key enzymes, transport systems and structural proteins. Given in alternate years. [3-0] This course is not eligible for Credit/D/Fail grading.
Advances in biochemical approaches. Topics vary. This course is not eligible for Credit/D/Fail grading.
Contemporary theoretical and experimental investigation of protein structure-function relationships. Topics will vary. This course is not eligible for Credit/D/Fail grading.
Contemporary theoretical and experimental investigation of protein structure-function relationships. Topics will vary. This course is not eligible for Credit/D/Fail grading.
Computational approaches to study protein and nucleic acids. This course is not eligible for Credit/D/Fail grading.
This course is not eligible for Credit/D/Fail grading.